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谢文荪医生

Profile picture of 谢文荪

高级顾问医生，肿瘤内科专科医生

理学士 (美国)、医学博士 (美国)、内科学 (美国)、肿瘤内科学 (美国)、美国内科医学委员会内科和肿瘤内科院士(美国)
肿瘤内科医生
预约就诊
安微尼亚山（Mount Alvernia）

Biography

Research

关注重点

Languages spoken

媒体

ICON中心位置

Memberships

发表文章

“我热爱肿瘤治疗的事业，因为它提供了以多种不同方式帮助患者的机会。”

Biography

介绍

谢文孙博士拥有三十年丰富的临床与科研经验，专精于各类癌症治疗，并积极致力于新型癌症诊断技术及分子靶向抗癌疗法的研发。他曾获罗德奖学金赴牛津大学攻读哲学与心理学，后于约翰霍普金斯大学取得医学学位，并在杜克大学完成内科培训，于约翰霍普金斯大学完成肿瘤内科/血液内科专科培训。 博士后阶段，谢文孙博士在理查德·安宾德教授实验室深造，开展关于爱泼斯坦-巴尔病毒在淋巴瘤及其他癌症中作用的实验室与临床研究。完成培训后，他以全职教员身份加入约翰霍普金斯大学医学院血液恶性肿瘤科，在患者诊疗、教学及科研领域全面开展工作。

进入私人执业后，他仍担任约翰霍普金斯大学兼职助理教授，并兼任新加坡国立大学癌症科学研究所首席研究员，积极参与癌症诊断与治疗的新型检测方法及疗法研发工作。 他目前担任ICON新加坡癌症中心研究委员会主席及国家医疗集团（NHG）领域专项审查委员会（DSRB）副主席，持续参与临床试验的实施与监督工作。

谢博士的研究兴趣集中于分子靶向癌症治疗、免疫疗法及分子诊断领域，曾主导多项国际研究，联合新加坡、香港、韩国、缅甸、菲律宾及美国等地的医疗中心，针对淋巴瘤、鼻咽癌和肝细胞癌开展新型治疗方案及创新性诊断检测的研究。他同时担任四十余项已完成或进行中的临床试验首席研究员，这些试验聚焦于肺癌、乳腺癌、胃肠道癌症及血液癌症的新型治疗方案。谢医生已发表逾80篇科学论文、摘要及专著章节，并频繁在区域性及国际医学科学会议上进行学术演讲。他致力于为现阶段癌症患者提供循证治疗，同时通过临床研究开发更有效的癌症治疗方案。
谢医生接受各类癌症转诊，临床专长领域涵盖淋巴瘤、头颈部及肺部癌症，以及肝胆胰癌症。

Research

DeLLphi-306

A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Tarlatamab Therapy in Subjects With Limited-Stage Small-Cell Lung Cancer (LS-SCLC) Who Have Not Progressed Following Concurrent Chemoradiation Therapy

Diagnosis

Lung cancer

Principal Investigator
Open for recruitment
查看 Trial

pionERA Breast Cancer

A Phase III Randomized, Open-Label Study Evaluating Efficacy and Safety of Giredestrant Compared With Fulvestrant, Both Combined With a CDK4/6 Inhibitor, in Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer With Resistance to Prior Adjuvant Endocrine Therapy

Diagnosis

Breast cancer

Open for recruitment
查看 Trial

INBRX-106

An Open-Label, Multicenter, First-in-Human, Dose-Escalation, Multicohort, Phase 1/2 Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab in Subjects With Locally Advanced or Metastatic Solid Tumors

Diagnosis

Advanced solid tumours

Principal Investigator
Open for recruitment
查看 Trial

发表文章

  • Cytidine Methylation of Regulatory Sequences Near the Pi-Class Glutathione S-Transferase Gene Accompanies Human Prostatic Carcinogenesis. Lee, W.H, Morton, R.A, Epstein, J.I., Brooks, J.D., Campbell, P.A., Bova, G.S., Hsieh, W.S., Isaacs, W.B., and Nelson, W.G. Natl.Acad. Sci. 1994; 91 (24): 11733-11737.

  • Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer. Hsieh, WS, Soo, RA, Peh, BK, Loh, T, Dong, DF, Soh, D, Wong, LS, Green, SR, Chiao, JT, Cui, CY, Lai, YF, Lee, SC, Mow, B, Soong, R., Salto-Tellez, M, Goh, BC. Clinical Cancer Research 2019; 15(4): 1435-42.

  • A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors. Low, SW, Tao, Q*, Ng, KM, Goh, HK, Shu, XS, Ambinder, RF, Srivastava, G, Shamay, M, Chan ATC, Popescu, NC, Hsieh, WS*. Oncogene 2011; 30(16): 1923-1935. *Co-Corresponding Author.

  • Plasma Epstein-Barr virus DNA as a marker of tumor response in Hodgkin lymphoma. Kanakry, JA, Li, HL, Gellert, LL, Lemas, MV, Hsieh, WS, Hong, FX, Tan, KL, Gascoyne, RD, Gordon, LI, Fisher, RI, Bartlett, NL, Stiff, P, Cheson, BD, Advani, R, Miller, TP, Kahl, BS, Horning, SJ, Ambinder, RF. Blood 2013; 121 (18): 3547-3553.

  • Methylation in cell-free Epstein-Barr virus DNA in patients with EBV+ Hodgkin lymphoma. Shamay, M, Kanakry, JA, Low, JSW, Horowitz, NA, Journo, G, Ahuja, A, Yontan, E, Elinor B, Eldad JD, Stone J, Woo WL, Hsieh WS, Xian R, Ambinder RF. Blood Advances 28;4(8):1624-1627, 2020

  • Kuss B, Nagarajan C, Hsieh WS, Cheah CY. Practical management of chronic lymphocytic leukemia with acalabrutinib. Leuk Lymphoma. 2022 Dec;63(12):2785-2794.

“我热爱肿瘤治疗的事业，因为它提供了以多种不同方式帮助患者的机会。”

关注重点

  • Head and neck cancer
  • Hepatobiliary cancer
  • Lung cancer
  • Lymphoma

Languages spoken

  • Mandarin

媒体

所属机构和会员关系

  • 美国癌症研究协会（AACR）会员
  • 新加坡ICON癌症中心研究委员会主席
  • 新加坡国立医疗集团（NHG）领域专项审查委员会（DSRB）副主席

发表文章

  • Cytidine Methylation of Regulatory Sequences Near the Pi-Class Glutathione S-Transferase Gene Accompanies Human Prostatic Carcinogenesis. Lee, W.H, Morton, R.A, Epstein, J.I., Brooks, J.D., Campbell, P.A., Bova, G.S., Hsieh, W.S., Isaacs, W.B., and Nelson, W.G. Natl.Acad. Sci. 1994; 91 (24): 11733-11737.

  • Pharmacodynamic Effects of Seliciclib, an Orally Administered Cell Cycle Modulator, in Undifferentiated Nasopharyngeal Cancer. Hsieh, WS, Soo, RA, Peh, BK, Loh, T, Dong, DF, Soh, D, Wong, LS, Green, SR, Chiao, JT, Cui, CY, Lai, YF, Lee, SC, Mow, B, Soong, R., Salto-Tellez, M, Goh, BC. Clinical Cancer Research 2019; 15(4): 1435-42.

  • A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors. Low, SW, Tao, Q*, Ng, KM, Goh, HK, Shu, XS, Ambinder, RF, Srivastava, G, Shamay, M, Chan ATC, Popescu, NC, Hsieh, WS*. Oncogene 2011; 30(16): 1923-1935. *Co-Corresponding Author.

  • Plasma Epstein-Barr virus DNA as a marker of tumor response in Hodgkin lymphoma. Kanakry, JA, Li, HL, Gellert, LL, Lemas, MV, Hsieh, WS, Hong, FX, Tan, KL, Gascoyne, RD, Gordon, LI, Fisher, RI, Bartlett, NL, Stiff, P, Cheson, BD, Advani, R, Miller, TP, Kahl, BS, Horning, SJ, Ambinder, RF. Blood 2013; 121 (18): 3547-3553.

  • Methylation in cell-free Epstein-Barr virus DNA in patients with EBV+ Hodgkin lymphoma. Shamay, M, Kanakry, JA, Low, JSW, Horowitz, NA, Journo, G, Ahuja, A, Yontan, E, Elinor B, Eldad JD, Stone J, Woo WL, Hsieh WS, Xian R, Ambinder RF. Blood Advances 28;4(8):1624-1627, 2020

  • Kuss B, Nagarajan C, Hsieh WS, Cheah CY. Practical management of chronic lymphocytic leukemia with acalabrutinib. Leuk Lymphoma. 2022 Dec;63(12):2785-2794.

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